LL Exsanguinate (Trickster/Gladiator) 15M+ DPS (6M on budget version)

Mandatory:
Cold Iron Point x2 - There is nothing that has a similar DPS increase, outside of perhaps some mirror crafts in standard
Thread of Hope - Without thread, it would be too difficult to fit in all the auras.
Glorious Vanity of Doryani - While this isn't mandatory, without it you should not go low life and drop pain attunement.


Helmet: Life and elder mod for increased physical damage and an open suffix to craft ailment avoidance

Body Armour: Warlord influence for +1 to socketed skill gems, some good life, and an open prefix for 10% of maximum life as extra energy shield


Gloves: Life and phyisical damage over time


Boots: Life, speed, and elemental ailment avoidance


Belt: Life and more life


Ring 1: Physical damage leech from a delve ring with some added life

Ring 2: Poachers mark from elder with some added life

Amulet Anoint: Hematophagy is likely the best here. More damage and more leeching. Alternatives are Crystal Skin to cap ailment avoidance, allowing you to drop a small cluster or not need an elevated shaper boot mod, or an increased life node.

Unique Jewels:
Replica pure talent is better than your average jewel, but you can skip this, especially if you need a jewel socket to help cap resistances

Thread of hope allows us to grab 7-8 nodes that would either be too far or have some weak nodes. Note you can grab spiritual aid if you have an extra point and are using a bone helm

Watcher's Eye: There isn't any watcher's eye worth using. You could make some adjustments to fit malevolence in and get a +% damage over time multiplier one, but its expensive and not that significant of a damage increase

Cluster Jewels:
These are pretty big. We want a large 8 passive with Master the Fundamentals and Battle-Hardened. The extra +10% elemental resistances are really helpful. Battle-Hardened is less important, but the increased armour is a good defensive boost. For the node from the suffix, its not as important as you likely won't use it, so just make sure the two nodes you do want are in front of the sockets.

The medium clusters are also pretty strong. The curse one gives us culling strike and increased vulnerability effect. The phyisical damage over time multiplier clusters have a lot of passives that add significant DPS. Note that PoB doesn't know how to calculate Blood Artist. In my PoB it is added as an implicit to the medium cluster.

Small clusters are a crutch. My gear was missing chaos resistances, so I filled it with a strong chaos cluster. I also was missing a bit of ailment avoidance since I didn't have elevated shaper boots and wanted to use a different anoint. Use or don't use these based on how your specific gear rolls. You might have perfect chaos res but need a cluster of an elemental resistance or want to grab some extra life.

Rare Jewels:

% increased maximum life and +% to physical damage over time multiplier are the targets, then fill in with resistances you may need. Global physical damage is also good.


Flask Setup:

Panicked Eternal Life Flask of I'm not sure what suffix would be best here yet.
____ Quicksilver Flask of Adrenaline to keep things moving
____ Silver Flask of Warding curse immunity with some movement and cast speed

Optional Uniques:
Bottled Faith is insane, but expensive. if you don't have a bottled faith, use a sulphur flask of iron skin