Implement health gating

There should be no such thing as one-hit kills at any level. If health gating (à la Borderlands 2 & 3) was added to the game, it would alleviate several of pain points. It would also restore a sense of fairness & actual skill, being that players would actually have a chance to react.

Death would still be a certainty to those whose builds are insufficient. You could even increase the threshold 75% or more health required for health gating to activate, instead of 50% as borderlands has it, and add a cooldown period.

Spamming health potions will also not save you if trying to brute forcing pinnacle content, since you would quickly run out of stock and be unable to heal at all.